Anti-hepatic fibrosis effect of ligustrazine or/and Paeonol was required interfering with HSC mitochondrial function. A, B. Western blot and PCR analyses of protein or gene of GSH, α-SMA, TNF-α and Caspase-3. 1: model group, 2: combined intervention group (Combined intervention with ligustrazine 20 μM/L and paeonol 25 μM/L), combined intervention group at the same time to add mitochondrial protective agent SS-31. #, P<0.05 and ##, P<0.01 vs. model group. *, P<0.05, **, P<0.01 and ***, P<0.001 vs. combined group.