Upregulation of genes in HCC. The GEPIA web-based tool with the TCGA database was used to compare the differences in expressions of the hub genes by normal and tumor tissues. The GEPIA database showed higher expression levels of CCNB1, CDC20, CCNB2, CDK1, SPC24, CENPW, ZWINT, PTTG1, AURKA, and UBE2C in HCC tissues compared with corresponding normal HCC tissues, respectively (P < 0.05). It suggested that these hub genes CCNB1, CDC20, CCNB2, CDK1, SPC24, CENPW, ZWINT, PTTG1, AURKA, and UBE2C might be related with HCC. GEPIA, Gene Expression Profiling Interactive Analysis; TCGA, The Cancer Genome Atlas; HCC, hepatocellular carcinoma.