Table 3.

KEGG pathway analysis showed significant signaling pathways associated with DEGs in HCC

Term	Count	DEGs
Metallothioneins bind metals	49	MT1A, MT1E, MT1F, MT1G, MT1H, MT1M, MT1X, MT2A, CDK1, CYP1A2, FOS, NUDT1, APOA4, NQO1, GSTM1, HBA1, HBA2, HBB, AKR1B10, GDF2, HFE, LCN2, S100A8, HAMP, ADRA1A, AVPR1A, C7, CXCL10, OXT, PTH1R, SAA1, CCL14, CXCL12, THY1, CD24, CCNB1, CRHBP, ADAMTS13, CDKN2A, GPC3, SFN, IGF2, SPP1, CCNB2, CDHR2, MEG3, E2F1, HMGA1, UBE2C
NABA MATRISOME ASSOCIATED	49	CRHBP, FCN2, GDF2, GPC3, CXCL2, HGF, HGFAC, IGF2, CXCL10, LGALS4, LPA, MDK, MMP11, PZP, S100A8, S100A10, CCL14, CCL20, CXCL12, SFRP5, FCN3, CHRD, TNFSF14, CXCL14, CLEC4M, COLEC10, ADAMTS13, MST1L, CLEC1B, MUC13, ANGPTL6, CLEC4G, INS-IGF2, CD34, CD74, DBH, ECM1, IGHA1, SAA1, THBS4, THY1, PLVAP, HFE, LY6E, OXT, SPP1, HAMP, ROBO1, PLA2G2A
Cell Cycle, Mitotic	52	BIRC5, CCNB1, CDK1, CDC20, CDKN2A, CENPF, E2F1, MCM2, MCM5, MYBL2, RRM2, AURKA, TK1, TOP2A, TYMS, CCNB2, AURKB, PTTG1, UBE2C, ZWINT, GMNN, CENPM, SPC24, SFN, CENPW, FOS, CDKN3, UBD, ATF5, UBE2S, RGCC, TCIM, KDM8, PRC1, CD74, IGF2, GLS2, HGF, SPP1, HFE, HAMP, AVPR1A, S100A8, CXCL12, CAPG, DCN, GBA, S100A10, CLTRN, ADRA1A, CXCL10, TNFSF14
Mitotic G1-G1/S phases	13	CCNB1, CDK1, CDKN2A, E2F1, MCM2, MCM5, MYBL2, RRM2, TK1, TOP2A, TYMS, GMNN, NUDT1
Binding and Uptake of Ligands by Scavenger Receptors	43	COL4A1, HBA1, HBA2, HBB, SAA1, MARCO, STAB2, APOA4, CYP1A2,PCK1, AKR1B10, ACSM1, UROC1, BLVRA, ENO3, ACSL4, GCKR, GSTM1, NNMT, TYMS, AADAT, HKDC1, BOLA2B, NQO1, HGF, THBS4, CDK1, LCN2, CD34, CRP, GLS2, BCO2, CD74, RRM2, S100A10, C9, GBA, SLC22A1, TK1, VWF, APOC2, HFE, IGHA1
Complement cascade	11	C7, C9, CRP, FCN2, FCN3, COLEC10, CFHR3, IGHA1, VWF, RGCC, MARCO
Caffeine metabolism	7	NAT2, CYP1A2, CYP2A6, CYP3A4, TK1, CYP2A7, AKR1B10