Fig. 2.

Immune methylation clusters and association with survival. (A) Selected immune cell type‐specific CpGs for immune methylation clusters across Lund cohort. Color bar on the right indicates the corresponding range for methylation β. Color bars on the left indicate the corresponding cell type for the CpG. Row names indicate corresponding gene names for the CpGs. (B) Balloon plot of absolute methylation difference per immune cell type between clusters. Balloon colors are representative of absolute Δβ, and balloon sizes indicate level of significance for comparisons. Color bar on the bottom left indicates the corresponding range for methylation absolute Δβ. P‐values calculated using Kruskal–Wallis and post hoc Dunn test, and multiple testing corrections performed across cell types for each comparison individually. (C, D) Kaplan–Meier plots of the immune methylation clusters for DMFS (regional lymph node metastases only) and DSS (all metastases except local recurrences), respectively. Numbers at risk and percentages at risk (within brackets) are indicated below each plot. P‐values calculated using log‐rank test. Maximum time to display on x‐axis has been clipped to 10 years.