Table 6. Amount of drug permeated per unit area in MEs compared with the aqueous saturated solution (control) through hairy and non-hairy pig skin (Mean±SD, n = 5) .
Formulation No. | Hairy Abdominal skin | Non-hairy ear skin | ||||
Q 8h (mg/cm 2 ) | Q 48h (mg/cm 2 ) | Q 8h (mg/cm 2 ) | Q 48h (mg/cm 2 ) | Ratio 8h | Ratio 48h | |
Control | 1.228±0.04 | 2.42±0.062 | 1.228±0.04 | 2.421±0.062 | - | - |
ME-1 | 3.04±0.42 | 5.05±0.23 | 9.35±0.23 | 15.4±0.78 | 3.07±0.03 | 3.04±0.01 |
ME-2 | 2.63±0.57 | 4.32±0.1 | 7.98±0.24 | 13.45±0.39 | 2.8±0.2 | 3.1±0.16 |
ME-3 | 2.36±0.06 | 4.2±0.02 | 7.03±0.05 | 12.21±0.17 | 2.9±0.1001 | 2.91±0.06 |
ME-4 | 2.29±0.01 | 3.75±0.05 | 6.42±0.05 | 10.75±0.25 | 2.8±0.005 | 2.86±0.02 |
ME-5 | 2.15±0.032 | 3.67±0.04 | 6.03±0.14 | 10.23±0.06 | 2.80±0.02 | 2.78±0.01 |
ME-6 | 2.35±0.04 | 2.99±0.04 | 6.73±0.1 | 11.9±0.21 | 2.86±0.09 | 2.98±0.01 |
ME-7 | 1.9±0.92 | 3.05±0.47 | 7.63±0.25 | 12.98±0.22 | 4.49±0.04 | 4.79±0.2 |
ME-8 | 1.38±0.014 | 2.26±0.03 | 8.93±0.06 | 14.92±0.55 | 6.44±0.01 | 6.48±0.15 |