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(a) ER, PR and HER-2 negative and lung metastasis of the 4T1 tumor. (b) Immunohistochemistry of bFGF, CD31, and VEGF in different stages of tumor growth in BALB/c TNBC syngeneic mice. Tumor volume of <100 mm3 is in early stage, 100-300 mm3 is in the intermediate stage, 300-500 mm3 is in the advanced stage and 500-1000 mm3 is in the end-stage.
