|
Drug
|
Coformer
|
Method of preparation
|
|
Acyclovir10
|
Tartaric acid, malonic acid, adipic acid |
Solvent evaporation |
|
Aripiprazole72
|
Orcinol |
|
|
Fexofenadine47
|
Tartaric acid |
|
|
Ibuprofen73,74
|
Nicotinamide |
|
|
Indomethacin75,76
|
Saccharin |
|
|
Itraconazole77
|
Succinic acid |
|
|
Myricetin78-81
|
Isonicotinamide, caffeine, proline, nicotinamide, 4-cyano pyridine |
|
|
Valsartan82
|
Succinic acid |
|
|
Aceclofenac83
|
Nicotinamide |
Neat grinding |
|
Aripiprazole72
|
Orcinol |
|
|
Etodolac84
|
Salicylic acid, benzoic acid, malonic acid, cinnamic acid, tartaric acid, PABA, hippuric acid, ferulic acid, maleic acid, glutaric acid |
|
|
Acemetacin85
|
Isonicotinamide, picolinamide, caprolactam |
Cooling crystallization |
|
Chloral hydrate86
|
Betain |
|
|
Darunavir87
|
Succinic acid |
|
|
Atorvastatin calcium88
|
Aspartame |
Slurry method |
|
Baicalein89
|
Nicotinamide |
High-pressure homogenization |
|
Caffeine90-92
|
Oxalic acid, glutaric acid |
Twin screw extrusion, spray congealing, cooling crystallization |
|
Carbamazepine90
|
Saccharin |
Twin screw extrusion |
|
Nicotinamide90
|
Trance Cinnamic acid |
|
|
Furosemide91
|
Anthranilamide, 4-toluamide, 2-picolinic acid, isoniazid, theophylline, 2,3,5,6-tetramethyl pyrazine, 2-picolinamide, pyrazine, piperazine |
Liquid-assisted grinding |
|
Gliclazide92
|
Sebacic acid, α-hydroxyacetic acid |
|
|
Entacapone93
|
Theophylline, nicotinamide, Acetamide isonicotinamide, pyrazinamide, isoniazid |
|
|
Salicylic acid94
|
Nicotinic acid, DL- phenylalanine, 6-hydroxy nicotinic acid, benzamide, isonicotinamide |
|
|
Piroxicam95
|
Sodium acetate, saccharin sodium, urea, nicotinamide, resorcinol |
Dry grinding |
|
Diacerin46
|
Urea, tartaric acid |
Solvent drop grinding |
|
Fenofibrate96
|
Nicotinamide |
|
|
Quercetin97
|
Caffeine, nicotinamide |
Electrospray technique |
|
Exemestane98
|
Maleic acid |
Slurry crystallization |
|
Isoniazide99
|
Vanillic acid, ferulic acid, caffeic acid, resorcinol |
|
|
Megestrol acetate98
|
Saccharin |
|
|
P-coumaric acid100
|
Nicotinamide |
|
|
Mefenamic acid101
|
Nicotinamide |
Co-milling |
