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. Author manuscript; available in PMC: 2020 Apr 30.
Published in final edited form as: Mol Pharm. 2020 Jan 13;17(2):461–471. doi: 10.1021/acs.molpharmaceut.9b00883

Figure 2: Interactions of pHLIP-PNA constructs with lipid bilayers.

Figure 2:

CD spectroscopy (A-D) and tryptophan fluorescence measurements (E-H) at various time points before and after reducing pH from 8 to 4 suggest that pHLIP-PNA constructs incubated with POPC vesicles undergo pH-triggered alpha-helix formation and transmembrane insertion, respectively. Maximum tryptophan fluorescence over time measurements (I) reveal differential kinetics of insertion for various pHLIP-PNA constructs.