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. 2020 May;20(5):607–617. doi: 10.1016/S1473-3099(19)30707-8

Table 2.

Potential predictors of bacterial burden in longitudinal sputum and face-mask samples over 24 h

24-h face-mask IS6110 output
24-h face-mask RD9 output
Correlation coefficient (95% CI) p value Correlation coefficient (95% CI) p value
Age −0·26 (−0·61 to 0·17) 0·21 −0·13 (−0·52 to 0·30) 0·53
Gender .. 0·89 .. 0·47
HIV status .. 0·48 .. 0·68
CD4 count* −0·28 (−0·65 to 0·20) 0·23 −0·11 (−0·53 to 0·36) 0·65
Duration of symptoms, weeks 0·18 (−0·26 to 0·55) 0·41 0·11 (−0·31 to 0·48) 0·56
Chest radiography grade −0·22 (−0·59 to 0·23) 0·32 −0·07 (−0·48 to 0·36) 0·75
Presence of cavitation on chest radiography .. 0·52 .. 0·38
Sputum acid-fast bacilli grade −0·08 (−0·54 to 0·41) 0·75 −0·02 (−0·49 to 0·47) 0·95
Sputum Xpert MTB/RIF grade 0·02 (−0·40 to 0·43) 0·92 −0·04 (−0·45 to 0·37) 0·84
Sputum culture§ 0·14 (−0·38 to 0·59) 0·58 0·07 (−0·44 to 0·54) 0·79
Cough frequency 0·10 (−0·33 to 0·50) 0·63 0·07 (−0·35 to 0·47) 0·73
Patient's perception of cough severity, visual analogue scale 0·28 (−0·18 to 0·63) 0·21 0·31 (−0·15 to 0·65) 0·53
Started tuberculosis treatment .. 0·68 .. 0·91
24-h sputum PCR signal content 0·17 (−0·30 to 0·57) 0·47 0·15 (−0·31 to 0·56) 0·49

Data represent the ability of variables to predict levels of IS6110 and RD9 signals detected in face-mask samples over 24 h, analysed by Spearman's correlation for continuous variables and the Mann-Whitney U test for categorical data.

*

CD4 count was recorded for all 20 HIV-positive patients.

Chest radiography grade and presence of cavitation was recorded for 23 patients.

Sputum acid-fast bacilli grade available for 17 patients.

§

Sputum culture results available for 16 patients.

Visual analogue scale recorded for 22 patients.