FIGURE 1.

The Hippo–YAP1/TAZ pathway in cardiac biology. Both YAP1 and TAZ are phosphorylated by core components, including Mst1/2, SAV1, Lats1/2, and MOB1, of the canonical Hippo pathway, and are subsequently degraded or stranded in the cytoplasm. Active YAP1/TAZ translocate to the nucleus, bind to transcriptional partners, and modulate downstream output in cardiac tissue. In addition, the Hippo-YAP1/TAZ pathway is regulated by several upstream pathways and cell-cell junctions. Line arrows indicate activation, whereas connector lines imply inhibition.