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. 2020 Apr 23;11:243. doi: 10.3389/fphar.2020.00243

TABLE 2.

Results obtained from the non-linear fittings performed to the average permeated protein per skin area (μgprotein/mmskin2) as a function of permeation time, for both plain mixtures of human insulin and ionic liquids and for the biofilms integrating ionic liquid (choline geranate 1:2) and loaded (or not) with human insulin.

Sample Hyperbolic function: y = (m1x)/(m2 + x)
Gompertz function: y = m1em2em3x
r
m1 m2 m1 m2 m3
Plain choline geranate 1:1 + human insulin —– —– 3.2065 7.2967 0.01372 0.95855
Plain choline geranate 1:2 + human insulin —– —– 4.5423 4.0200 0.002396 0.97723
Plain choline oleate 1:1 + human insulin 1.0934 15.849 —– —– —– 0.83923
Plain choline oleate 1:2 + human insulin —– —– 3.1699 4.1891 × 109 0.2286 0.98815
Plain human insulin —– —– 0.3865 67.6410 0.02888 0.67167
Biofilm with choline geranate 1:2 and human insulin 1.5138 596.48 —– —– —– 0.75531
Plain biofilm with human insulin —– —– 0.001654 −0.8695 1.6417 1.00000