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. 2020 Apr 30;217(6):e20200678. doi: 10.1084/jem.20200678

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© 2020 Vardhana and Wolchok

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Figure 3. — Immune dysregulation during chronic viral infections. (A and B) During acute viral infections (A), early innate and adaptive immune function lead to viral suppression, followed by development of adaptive immunity. During chronic viral infections (B), persistent virus leads to T cell depletion and exhaustion while triggering ongoing innate immune inflammation. NK, natural killer.