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. 2020 Apr 23;11:381. doi: 10.3389/fphys.2020.00381

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Copyright © 2020 Xie, Huang, Ling, Qin, Wang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemerin/CMKLR1-induced pyroptosis was mediated by NLRP3. (A) EthD-III staining (red), DAPI (nuclei; blue), and merged (pink); scale bar: 50 μm. TUNEL staining of H9c2 cardiomyocytes, dark brown staining represent nuclear DNA fragmentation; scale bar: 20 μm. (B) Quantitative analysis of EthD-III-positive cells. (C) Quantitative analysis of TUNEL-positive cells in each group. (D) Relative secreted levels of LDH in the different groups. Data were presented as means ± SEM from three independent experiments. * p < 0.05 vs. Ctrl; ** p < 0.01 vs. Ctrl; ^§ p < 0.05 vs. DCM+NC; ^§§ p < 0.01 vs. Chemerin+NC; ^#p < 0.05 vs. Chemerin+CMKLR1-siRNA; ^ap < 0.05 vs. Chemerin+NLRP3-siRNA; NC, negative control; Chem, chemerine; N3-siRNA, NLRP3-siRNA.