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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Biomaterials. 2020 Feb 27;243:119920. doi: 10.1016/j.biomaterials.2020.119920

Figure 1.

Figure 1.

Macrophage ablation reduces peri-implant Wnt signaling in bone. Macrophages were ablated in MaFIA mice by treatment with AP20187 daily for 3d prior to surgery and every other day post-operatively. Control groups only underwent the 3d ablation process, while sham, rough, and rough-hydro groups underwent treatment until sacrifice at 1, 3 or 7d post-surgery (n=6 per group). Expression of Wnt ligand genes in peri-implant tissue was measured using qPCR. Results are normalized to expression of the housekeeping gene Gapdh and presented as fold-change (2-ΔΔCt). A) Heat map demonstrating the change in Wnt gene expression for with macrophage ablation in Sham, Rough, and Rough-Hydro peri-implant tissue. B) Comparison of Wnt gene expression on Rough-Hydro surfaces in Control (green) and Ablated (orange) animals. p<0.05: A vs. respective Control.