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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Biomaterials. 2020 Feb 27;243:119920. doi: 10.1016/j.biomaterials.2020.119920

Figure 8.

Figure 8.

Loss of Wnt signaling attenuates inflammatory cytokine production in response to Ti surface cues. Macrophageal Wnt secretion was inhibited A) pharmacologically using Wnt-C59 or B) genetically by treating Csf1riCre+; Wlsfl/fl mice with tamoxifen prior to culture of macrophages. Pro-(IL-1β, IL-6, TNF-α) and anti-inflammatory (IL4, IL-10) cytokines were measured by ELISA and normalized to DNA quantity in each sample (n=6 per group). p<0.05: # vs. TCPS, $ vs. Smooth, % vs. Rough, A vs. Control of corresponding group.