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. 2020 Apr 15;12(4):365–382. doi: 10.4251/wjgo.v12.i4.365

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Mesenchymal stem cells promote colorectal cancer progression via CCR5[99]. A: Scheme of co-inoculation mice model. HCT116-EV, HCT116 cells transfected with empty vector; HCT116-CCR5, HCT116 cells transfected with CCR5. B: Tumor volume curves in HCT116-EV and HCT116-CCR5 co-cultured with MSCs. C: Representative images of tumors and histological findings in HCT116-EV + MSCs and HCT116-CCR5 + MSCs groups. D: Scheme of treatment procedure. E: Tumor volume curves in HCT116-EV + MSCs and HCT116-CCR5 + MSCs groups. Dotted lines show treatment group with maraviroc 30 mg/kg/d, and solid lines show control group with vehicles.