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Metformin decreases Aβ levels in APP/PS1 mice. The levels of (a) Aβ1-40 and (b) Aβ1-42 in the brain of APP/PS1 mice. ThT staining of the brain slides in APP/PS1 mice. Experimental values were expressed as the mean ± SEM (n = 6 per group). ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 vs. WT; #p < 0.05, ##p < 0.01, and ###p < 0.001 vs. APP/PS1. Bar: 100 μm.
