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. 2020 Jan 21;318(4):E480–E491. doi: 10.1152/ajpendo.00425.2019

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Fig. 4. — Treatment with pasteurized Akkermansia muciniphila increases serum levels of PTH. Twelve-week-old female mice treated with either vehicle (Veh) or pasteurized Akkermansia muciniphila (pAkk) by daily oral gavage during 28 days, starting 3 days before ovariectomy (Ovx) or sham surgery. Calcium metabolism was analyzed at the end of the experiment by measuring serum levels of calcium (n = 8–12; A), calcium-creatinine ratio in urine (n = 4–6; B), serum levels of parathyroid hormone (PTH; n = 8–12; C), and mRNA expression of transient receptor potential cation subfamily V member 5 (Trpv5; D) in kidney (n = 8–12). Statistical analysis of serum PTH was performed on log-transformed data. The overall effect of treatment (Veh/pAkk) and surgical procedure (Sham/Ovx) and their interaction were calculated using two-way ANOVA followed by Dunnett’s post hoc test to correct for multiple comparisons between all groups vs. vehicle-treated sham mice, *P ≤ 0.05.