Table 1.

Organ weights

	Surgery		Two-Way ANOVA (P Value)
Treatment	Sham	Ovx	Sham/Ovx	Veh/pAkk	Interaction
Uterus, %BW
Veh	0.332 ± 0.037	0.062 ± 0.004	P ≤ 0.01	NS	NS
pAkk	0.350 ± 0.070	0.054 ± 0.006
Thymus, %BW
Veh	0.219 ± 0.006	0.284 ± 0.009	P ≤ 0.01	NS	NS
pAkk	0.217 ± 0.016	0.261 ± 0.010
Kidney, %BW
Veh	1.022 ± 0.018	1.016 ± 0.019	P ≤ 0.05	NS	P ≤ 0.05
pAkk	1.094 ± 0.034	1.003 ± 0.012
Liver, %BW
Veh	4.085 ± 0.092	4.378 ± 0.062	NS	NS	NS
pAkk	4.285 ± 0.191	4.365 ± 0.070
M. quadriceps, %BW
Veh	0.669 ± 0.031	0.639 ± 0.031	NS	NS	NS
pAkk	0.696 ± 0.034	0.631 ± 0.029

Twelve-week-old female mice were treated with either vehicle (Veh) or pasteurized Akkermansia muciniphila (pAkk) by daily oral gavage during 28 days, starting 3 days before ovariectomy (Ovx) or sham surgery. At the end of the study tissues were dissected and weighed. Values are given as means ± SE and expressed relative to body weight (BW) (n = 8–12). Two-way ANOVA to test the effect of treatment (Veh/pAkk) and surgical procedure (Sham/Ovx) and their interaction was used.