Sleep fragmentation (SF) altered serum catecholamine levels. Mean ± SE serum norepinephrine (NE; A–C) and corticosterone (cort; D–F) levels in vehicle-injected or chemically sympathectomized mice subjected to acute SF (n = 6/group, A and D), chronic SF (n = 6/group, B and E), or 1 wk of recovery following chronic SF (n = 6/group, C and F). 6-OHDA, 6-hydroxydopamine. Significant effect of SF (*) and chemical sympathectomy (#) as determined by Bonferroni post hoc test followed by 2-way ANOVA. For statistical significance, α was set at 0.05.