Fig. 5.

Mice lacking Pdgfa develop emphysema. In vivo µCT and lung function measurements of mouse lungs showing lung density in Hounsfield units (HU) (A) and functional residual capacity (FRC) volume (B), lung tissue compartment volume (C), lung air-to-tissue volume ratio (D), dynamic compliance (E), static compliance (F), pressure-volume loops (G), and Hysteresis (H). Hysteresis and pressure-volume loops were calculated using PV-sP. Control mice n = 9–10; knockout mice n = 8–9. Values are given as means ± SE. Statistical analysis was done using Student’s two-tailed unpaired t test and statistical significance is indicated as follows: ***P < 0.001 and ****P < 0.0001