Fig. 5.
Results derived from deep inflation and pressure-volume (P-V) maneuvers. A: partial P-V loops and the related parameters that were derived from these curves (C). Cst, static compliance; A, an estimate of inspiratory capacity; k, shape constant that describes the curvature of the deflation arm; area, area between the inflation and deflation curves. B: inspiratory capacity as measured with the deep inflation maneuvers. D: full-range P-V loops and the derived parameters, including total lung capacity (TLC), vital capacity (VC), residual volume (RV), compliance (C), volume at 10 cmH2O as percentage of TLC (V10_TLC), and an estimate of functional residual capacity (FRC). All parameters were significantly decreased in Crtap knockout (KO) compared with wild-type (WT)/Het mice. N = 8–10 each genotype. Student’s t test.