Table 1.

Results from the plethysmography measurements combining male and female data

	WT/Het	CrtapKO	t Test (P Value)
Age 3–5 mo, n	18	18
Weight, g	24.43 ± 3.5	20.81 ± 2.5	0.001
F, breaths/min	356.13 ± 35.9	354.47 ± 38.8	0.89
Ti, s	0.058 ± 0.0056	0.059 ± 0.0072	0.64
Te, s	0.157 ± 0.0255	0.141 ± 0.0187	0.04
Ttot, s	0.215 ± 0.0299	0.2002 ± 0.0242	0.11
Ti/Te	0.372 ± 0.042	0.417 ± 0.039	0.002
Ti/Ttot	0.27 ± 0.0222	0.29 ± 0.0195	0.002
Ti/Ttot %	27.08	29.4
VT, mL	0.28 ± 0.0294	0.23 ± 0.0264	0.000002
VT/g, mL/g	0.012 ± 0.002	0.011 ± 0.0016	0.24
V̇e, mL/min	100.94 ± 18.27	80.65 ± 15.02	0.0009
V̇e/g, mL·min−1·g−1	4.21 ± 0.955	3.92 ± 0.791	0.33
VT/Ti, mL/min	294.29 ± 49.72	235.19 ± 41.03	0.0004
VT/Ti/g, mL·min−1·g−1	12.31 ± 2.81	11.46 ± 2.32	0.32

Values are means ± SD. WT, wild type; KO, knockout; F, respiratory rate; T_i, inspiratory time; T_e, expiratory time; T_tot, total cycle time; V_T, tidal volume; V̇e, minute ventilation. Values in bold are significant (P < 0.05; Student’s t test).