Table 2.

Results from the plethysmography measurements: data from male and female mice are shown separately

	Males			Females
	WT/Het	CrtapKO	t Test (P Value)	WT/Het	CrtapKO	t Test (P Value)
Age 3–5 mo, n	12	12		6	6
Weight, g	25.96 ± 2.87	22.21 ± 1.16	0.0003	21.36 ± 2.57	18 ± 2.02	0.03
F, breaths/min	367.2 ± 35.52	351.16 ± 47.16	0.35	333.97 ± 26.96	361.08 ± 12.12	0.048
Ti, s	0.057 ± 0.006	0.06 ± 0.008	0.32	0.06 ± 0.005	0.057 ± 0.004	0.32
Te, s	0.15 ± 0.024	0.143 ± 0.022	0.42	0.171 ± 0.025	0.139 ± 0.008	0.014
Ttot, s	0.207 ± 0.029	0.202 ± 0.029	0.69	0.23 ± 0.028	0.196 ± 0.008	0.015
Ti/Te	0.381 ± 0.035	0.421 ± 0.041	0.017	0.355 ± 0.052	0.41 ± 0.037	0.061
Ti/Ttot	0.276 ± 0.018	0.296 ± 0.02	0.018	0.261 ± 0.028	0.291 ± 0.019	0.057
Ti/Ttot %	27.56	29.56		26.1	29.07
VT, mL	0.287 ± 0.028	0.227 ± 0.024	0.00001	0.265 ± 0.027	0.226 ± 0.031	0.044
VT/g, mL/g	0.011 ± 0.002	0.010 ± 0.001	0.17	0.012 ± 0.001	0.012 ± 0.0008	0.84
V̇e, mL/min	107.28 ± 19.2	80.31 ± 17.54	0.0016	88.23 ± 5.72	81.33 ± 9.42	0.15
V̇e/g, mL·min−1·g−1	4.23 ± 1.15	3.621 ± 0.8	0.14	4.167 ± 0.432	4.522 ± 0.286	0.12
VT/Ti, mL/min	308.03 ± 55.91	233.62 ± 48.02	0.002	266.79 ± 12.84	238.34 ± 25.13	0.033
VT/Ti/g, mL·min−1·g−1	12.15 ± 3.36	10.54 ± 2.22	0.18	12.85 ± 1.37	13.35 ± 1.12	0.5

Values are means ± SD. WT, wild type; KO, knockout; F, respiratory rate; T_i, inspiratory time; T_e, expiratory time; T_tot, total cycle time; V_T, tidal volume; V̇e, minute ventilation. Values in bold are significant (P < 0.05; Student’s t test).