Table 3.

Values of model parameters estimated by fitting the model to protocol 2 kinetic data from individual lungs in the absence or presence of verapamil in the perfusate

	P1S1, mL/min	P2S2, mL/min	Kpgp, mL/min	k̄2, mL/min	k−2, min−1	Kd3	Δψm, mV	CV, %
R6G	48.56 ± 1.03	0.75 ± 0.09	5.77 ± 0.50	11.25 ± 0.67	0.117 ± 0.007	0.030 ± 0.004	−117.5 ± 0.3	10.2 ± 1.1
R6G + verapamil	46.54 ± 0.35	1.07 ± 0.19	0	6.90 ± 0.45*	0.178 ± 0.023*	0.018 ± 0.003*	−131.2 ± 5.8	9.3 ± 0.4

Values are means ± SE (n = 6 and 5 without and with verapamil, respectively). K_d1 (%BSA) was fixed at the value in Table 2. CV, coefficient of variation; R6G, rhodamine 6G.

^*Different from without verapamil (t test, P < 0.05).