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Methylmercury (MeHg) exposure elicited giant inhibitory postsynaptic currents (IPSCs) in lumbar spinal motor neurons. Representative current recordings of 3 distinct neurons show giant IPSCs compared with spontaneous IPSCs. The amplitude, kinetics, and total charge (integrated area under the curve) were significantly larger for the giant IPSCs compared with the normal IPSC currents, only occurred in the presence of MeHg, and were not seen in every slice.
