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. 2020 Mar 18;123(4):1536–1551. doi: 10.1152/jn.00587.2019

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Licensed under Creative Commons Attribution CC-BY 4.0: © the American Physiological Society. ISSN 0022-3077.

Licensed under Creative Commons Attribution CC-BY 4.0: © the American Physiological Society.

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Fig. 6. — Effect of PVI suppression on auditory cortex responses. A: negligible reduction in baseline activity (R_min) produced by PVI suppression during low-contrast stimulation. B: a more substantial increase in the maximum response (R_max) was also observed. C: a small subtractive change in the offset of responses occurred during PVI suppression. D: the asymmetrical effects on R_min and R_max led to an increase in gain during PVI suppression. E: a small reduction in R_min was also observed under high-contrast stimulation. F: a similar increase in R_max was observed under high-contrast stimulation. G: unlike under low-contrast stimulation, PVI suppression produced a small increase in offset during high-contrast stimulation. H: the robust increase in gain observed under low-contrast stimulation was also observed during high-contrast stimulation. I: the similarity of the effects on gain under low and high-contrast stimulation resulted in this manipulation leaving the strength of contrast gain control unaffected. Arch, archearhodopsin; MUA, multiunit activity; PVI, parvalbumin-positive interneurons; R_min; 5th percentile of the response of the multiunit activity; R_max, maximum response as the 95th percentile; S, range of responses in a particular light condition (“on” vs. “off”) and contrast condition (“low” vs. “high”).