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. 2020 Feb 26;123(4):1332–1341. doi: 10.1152/jn.00029.2020

Fig. 1.

Fig. 1.

Region-specific effects of human immunodeficiency virus (HIV)-1 transactivator of transcription protein (Tat) on neuronal gain. A: response of a representative layer 2/3 medial prefrontal cortex (mPFC) pyramidal neuron obtained from a TatNeg animal (left, black traces) and TatPos animal (right, orange traces) to current steps of −100 pA and +200 pA (square pulses illustrated below the voltage traces). B: complete neuronal gain curves constructed using data from 14 TatNeg and 17 TatPos neurons indicate that HIV-1 Tat expression was associated with a clear increase in excitability of mPFC layer 2/3 pyramidal neurons (see results for additional details). C: response of a representative CA1 pyramidal neuron obtained from a TatNeg animal (left, black traces) and TatPos animal (right, orange traces) to current steps of −100 pA and +50 pA (square pulses illustrated below the voltage traces). D: complete neuronal gain curves constructed using data from 17 TatNeg and 17 TatPos neurons indicate that HIV-1 Tat expression was associated with a clear but selective decrease in excitability of CA1 pyramidal neurons, in response to current injections of <100 pA (see results for additional details).