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. Author manuscript; available in PMC: 2021 Apr 16.
Published in final edited form as: Mol Cell. 2020 Mar 23;78(2):210–223.e8. doi: 10.1016/j.molcel.2020.03.004

Figure 1. Methionine Restriction Stimulates Global, Dynamic Histone PTM Response.

Figure 1.

(A) Metabolic pathway diagram illustrating changes in Met-cycle metabolite abundance after 24 hours and 5 weeks of Met-restriction in HCT116 cells and C57BL/6J liver, respectively. n=5, error bars represent SD, *p<0.05 (Welch’s t-Test). (B-C) Plots illustrating global, relative 5mC DNA methylation levels during Met-restriction. n≥3, error bars represent SD, *p<0.05 (Welch’s t-Test) (D-E) Hierarchical clustered heatmaps of LC-MS/MS generated log2 fold-change stoichiometric histone H3 peptide proteoform values relative to 0-hour or chow diet controls in HCT116 cells and C57BL/6J liver, respectively. n≥3, *p<0.05, **p<.01 (Welch’s t-Test). See also Table S1 and Figure S1.