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. 2020 Apr 14;5(16):9301–9310. doi: 10.1021/acsomega.0c00189

Table 1. MICs of Cathelicidin-DM and Its Derivativesa.

  MICs (μg/mL)
bacterial strains cathelicidin-DM cath-DM-CT1 cath-DM-CT2 cath-DM-CT3 cath-DM-NT cath-DM-NCT1 cath-DM-NCT2 Amp cathelicidin-DM after incubation in 50% serum
Gram-Positive Bacteria
S. haemolyticus (CI 1410970016) 12   6 3     3    
E. faecalis (MDR 14U0445) 12             2  
S. aureus ATCC25923 12 12           0.15  
Gram-Negative Bacteria
E. coli ATCC25922 12             0.3  
E. coli (MDR 13U1780) 12 12 12         32  
E. coli (MDR 13A10022) 12             32  
S. paratyphi A (CI 1410BL0513) 6 6   12     6 32 6
C. freundii (CI 1410UR0112) 12     6     12   12
K. pneumoniae (MDR 13U1752) 6     6       32 6
K. pneumoniae (MDR 13A11923) 6             32 6
K. pneumoniae (XDR 13A13361) 6 6   3     6 32 6
a

Note: CI, clinically isolated strain; MDR, multi-drug-resistant clinical isolate; XDR, extensive drug-resistant clinical isolate; (-) no detectable activity at a dose of 48 μg/mL.