Table 1. MICs of Cathelicidin-DM and Its Derivativesa.
MICs (μg/mL) |
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---|---|---|---|---|---|---|---|---|---|
bacterial strains | cathelicidin-DM | cath-DM-CT1 | cath-DM-CT2 | cath-DM-CT3 | cath-DM-NT | cath-DM-NCT1 | cath-DM-NCT2 | Amp | cathelicidin-DM after incubation in 50% serum |
Gram-Positive Bacteria | |||||||||
S. haemolyticus (CI 1410970016) | 12 | 6 | 3 | 3 | |||||
E. faecalis (MDR 14U0445) | 12 | 2 | |||||||
S. aureus ATCC25923 | 12 | 12 | 0.15 | ||||||
Gram-Negative Bacteria | |||||||||
E. coli ATCC25922 | 12 | 0.3 | |||||||
E. coli (MDR 13U1780) | 12 | 12 | 12 | 32 | |||||
E. coli (MDR 13A10022) | 12 | 32 | |||||||
S. paratyphi A (CI 1410BL0513) | 6 | 6 | 12 | 6 | 32 | 6 | |||
C. freundii (CI 1410UR0112) | 12 | 6 | 12 | 12 | |||||
K. pneumoniae (MDR 13U1752) | 6 | 6 | 32 | 6 | |||||
K. pneumoniae (MDR 13A11923) | 6 | 32 | 6 | ||||||
K. pneumoniae (XDR 13A13361) | 6 | 6 | 3 | 6 | 32 | 6 |
Note: CI, clinically isolated strain; MDR, multi-drug-resistant clinical isolate; XDR, extensive drug-resistant clinical isolate; (-) no detectable activity at a dose of 48 μg/mL.