Fig. 1.

The physique, body weight, femur length, and bone mineral density (BMD) of the whole femur of C57BL/6J (WT) and transient receptor vanilloid 1 and 4 (TRPV1 and TRPV4) double knockout (DKO) mice.

(A) The gross appearances and (B) three-dimensional images of the whole-body skeletons of WT and DKO mice are shown. The mean values of (C) body weight measured by a digital scale, (D) femur length measured by a digital caliper, and (E) BMD of the whole femur analyzed by DXA of WT and DKO mice are shown (n = 8 in each group). The data are presented as means ± SEM. Student's t-test, **p < 0.01 compared to WT.