Fig. 2.

Alterations in active K-Ras conformations due to oncogenic mutations. Left panels: changes in pairwise residue distances ($\mathrm{\Delta }\stackrel{-}{R}$_ij) in active K-Ras due to mutation. Positive $\mathrm{\Delta }\stackrel{-}{R}$_ij values indicate divergent pairs (red); negative $\mathrm{\Delta }\stackrel{-}{R}ij$ values indicate convergent pairs (blue). Right panels: all $\mathrm{\Delta }\stackrel{-}{R}$_ij values averaged for each residue, ($\langle \mathrm{\Delta }\stackrel{-}{R}i\rangle )$. Positive values indicate that the mutation causes a residue to move away from its neighbors; negative values indicate that a residue moves close to its neighbors. The predominant behavior for all studied mutants is positive (A-B) K-Ras^G12C (C-D) K-Ras^G12V (E-F) K-Ras^G13D (G-H) K-Ras^Q61H. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)