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Changes in K-Ras dynamics due to oncogenic mutations. Y-axis shows the RMSF values of residues. GTP-bound active K-Ras (black: WT, red: mutant) (A) G12C-GTP (B) G12V-GTP (C) G13D-GTP (D) Q61H-GTP; GTP-bound active K-Ras (grey: WT, pink: mutant) (E) G12C-GDP (F) G12V-GDP (G) G13D-GDP (H) Q61H-GDP. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
