(a) The effect of progesterone administration at 2 h after TBI on CSF levels of IL-6 (ng/L) in OVX rats (n = 7). ∗∗∗P < 0.001, vs. Sh.∗∗P < 0.01, vs. Sh. ##p < 0.01, vs. Veh. (b) The effect of capsule form of progesterone on IL-6 levels of IL-6 (ng/L) in OVX rats (n = 7). ++, P < 0.01.vs Cveh. (c) Changes in percentage of CSF of IL-6 after TBI compared with vehicle in rats treated with progesterone (n = 7). No significant different between LP, HP or CP groups. Sh, sham; Veh, vehicle; LP, low progesterone; HP, high progesterone; CP, progesterone capsule; Cveh, capsule vehicle.