Table 3.
Seroconversion to Poliovirus Types 1, 2, and 3 at 14 and 22 Weeks of Life, by Study Arm
| Age, Type, Measure | Arm A | Arm B | Arm C | Arm D | Arm E |
|---|---|---|---|---|---|
| 14 wk | |||||
| Type 1 | |||||
| Seroconversion | |||||
| Proportion | 96/138 | 130/144 | 121/139 | 119/138 | 110/134 |
| Percentage (95% CI) | 70 (63–79) | 90 (85–94) | 87 (83–94) | 86 (69–91) | 82 (76–88) |
| Titer,a median (95% CI) | 831 (455 to ≥1448) | ≥1448 (≥1448 to ≥1448) | ≥1448 (≥1448 to ≥1448) | ≥1448 (≥1448 to ≥1448) | 1152 (1152 to ≥1448) |
| Type 2 | |||||
| Seroconversion | |||||
| Proportion | 98/138 | 26/144 | 19/139 | 28/138 | 119/134 |
| Percentage (95% CI) | 71 (66–78) | 18 (13–25) | 14 (9–21) | 20 (13–23) | 89 (82–93) |
| Titer,a median (95% CI) | 181 (113–288) | 362 (228–724) | 724 (455–910) | 416 (228–724) | 1152 (724 to ≥1448) |
| Type 3 | |||||
| Seroconversion | |||||
| Proportion | 126/138 | 133/144 | 120/139 | 119/138 | 100/134 |
| Percentage (95% CI) | 91 (86–96) | 92 (86–95) | 86 (80–92) | 86 (80–92) | 75 (67–82) |
| Titer,a median (95% CI) | 724 (576–1152) | 588 (455–724) | 588 (455–910) | 446 (408–724) | 362 (455–724) |
| 22 wk | |||||
| Type 1 | |||||
| Seroconversion | |||||
| Proportion | 111/138 | 139/144 | 131/139 | 132/138 | 126/134 |
| Percentage (95% CI) | 80 (72–86) | 97 (93–100) | 94 (90–98) | 96 (92–99) | 94 (90–98) |
| Titer,a median (95% CI) | 445 (227–910) | ≥1448 (≥1448 to ≥1448) | ≥1448 (≥1448 to ≥1448) | ≥1448 (≥1448 to ≥1448) | 1152 (910 to ≥1448) |
| Type 2 | |||||
| Seroconversion | |||||
| Proportion | 116/138 | 28/144 | 74/139 | 68/138 | 125/134 |
| Percentage (95% CI) | 84 (78–90) | 19 (13–27) | 53 (44–61) | 49 (40–57) | 93 (89–98) |
| Titer,a median (95% CI) | 111 (90–181) | 181 (113–288) | 32 (28–57) | 39 (23–114) | 724 (650–1152) |
| Type 3 | |||||
| Seroconversion | |||||
| Proportion | 129/138 | 135/144 | 136/139 | 130/138 | 114/134 |
| Percentage (95% CI) | 93 (89–98) | 94 (90–98) | 98 (95–100) | 94 (90–98) | 85 (79–91) |
| Titer,a median (95% CI) | 446 (362–910) | 588 (455–910) | 1261 (910 to ≥1448) | 1176 (1031 to ≥1448) | 294 (288–515) |
Analysis was performed on subjects who provided sera at birth and at 14 and 22 weeks of age and completed all vaccinations.
Abbreviation: CI, confidence interval.
a
Data are for children who seroconverted.