Table 2.

Summary of Treatment Groups

Group No.	Compound(s)	Concentration(s)	Treatment Regimen	Total No.
5-day treatment
1	Control	NA	PBS and methylcellulosea	20b
2	OSc	25 mg/kg	Once daily	20
3	LAOd	1.5 mg/kg	Once	20
4	FA20e	20 mg/kg	Once daily	20
5	FA30f	30 mg/kg	Once daily	20
6	OS + FA20	25 mg/kg + 20 mg/kg	Once daily	20
7	LAO + FA20	1.5 mg/kg + 20 mg/kg	Once (LAO)/once daily (FA20)	20
8	OS + FA30	25 mg/kg + 30 mg/kg	Once daily	20
9	LAO + FA30	1.5 mg/kg + 30 mg/kg	Once (LAO)/once daily (FA30)	22g
28-day treatment
10	Control	NA	PBS and methylcellulosea	17h
11	OS	25 mg/kg	Once daily	17
12	LAO	1.5 mg/kg	Once per week	17
13	FA20	20 mg/kg	Once daily	17
14	FA30	30 mg/kg	Once daily	17
15	OS + FA20	25 mg/kg + 20 mg/kg	Once daily	17
16	LAO + FA20	1.5 mg/kg + 20 mg/kg	Once per week (LAO)/once daily (FA20)	17
17	OS + FA30	25 mg/kg + 30 mg/kg	Once daily	17
18	LAO + FA30	1.5 mg/kg + 30 mg/kg	Once per week (LAO)/once daily (FA30)	17

Abbreviations: FA20, low-dose favipiravir (20 mg/kg); FA30, high-dose favipiravir (30 mg/kg); LAO, laninamivir octanoate; NA, not applicable; OS, oseltamivir phosphate; PBS, phosphate-buffered saline.

^aPBS (intranasal control) was administered once per week; methylcellulose (oral control) was administered daily.

^bFive mice for the survival study and 15 mice to assess lung virus titers (5 time points; 3 mice per time point).

^cAdministered orally.

^dAdministered intranasally.

^eAdministered orally.

^fAdministered orally.

^gTwo extra mice were available, which were added to group 9.

^hFive mice for the survival study and 12 mice to assess lung virus titers (4 time points; 3 mice per time point).