Table 4.

Viral Samples With Reduced Sensitivity to Oseltamivir Carboxylate and Laninamivir, Sorted by Day of Sampling

Sample No.	Group No.a	Treatmenta	Day of Sampling	IC50, nM
				OS-C	LA
111	16	LAO + FA20	14	83	12
181	16	LAO + FA20	21	178	27
182	16	LAO + FA20	21	94	13
187	18	LAO + FA30	21	85	32
188	18	LAO + FA30	21	141	37
189	18	LAO + FA30	21	189	25
220	16	LAO + FA20	28	200	24
221	16	LAO + FA20	28	222	14
222	16	LAO + FA20	28	216	27
226	18	LAO + FA30	28	82	45
227	18	LAO + FA30	28	215	21
228	18	LAO + FA30	28	107	35
234	16	LAO + FA20	37	60	44
235	18	LAO + FA30	38	250	29
238	18	LAO + FA30	39	109	21
243	16	LAO + FA20	41	241	31
248	16	LAO + FA20	44	166	21
250	16	LAO + FA20	45	37	13
264	16	LAO + FA20	63	86	22

Abbreviations: FA20, low-dose favipiravir (20 mg/kg); FA30, high-dose favipiravir (30 mg/kg); IC₅₀, 50% inhibitory concentration; LA, laninamivir; LAO, laninamivir octanoate; OS-C, oseltamivir carboxylate.

^aDetails of treatment groups and treatments are shown in Table 2.