Figure 3.

Brain magnetic resonance imaging (MRI) evolution of the second patient. Initial MRI—axial T2 imaging (A-B) and axial fluid-attenuated inversion recovery (FLAIR) imaging (C) showing hyperintensity in right temporoinsular area; post-herpes simplex virus encephalitis (HSVE) anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis—coronal (D) and axial (E) T2 imaging with hyperintensity evolving temporomesial area; follow-up imaging (after immunotherapy and approximately 24 weeks after initiation of acyclovir)—axial T2 imaging (F) and axial FLAIR imaging (G-H) showing hyperintensity with atrophy in the right temporoinsular area, and atrophy and gliosis in the right temporal area and hippocampus, respectively.