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. 2020 Apr 29;21:18. doi: 10.1186/s12868-020-00565-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The role of COX5A over-expression on neurites outgrowth and cell apoptosis in vitro. a Representative images of Tuj1 immunofluorecent staining in each group, DAPI labeled nucleus (blue), Tuj1 labeled neurons (red). Scale bar = 50 μm. b TUNEL assay in neurons after COX5A over-expression under OGD condition. DAPI labeled nucleus (blue), red color represents positive apoptotic cells. Scale bar = 100 μm. c Quantitative histogram of average cell number per field. d Bar chart of average length of neuites. e The apoptosis rate of the neurons, which was indicated by tunel/DAPI. OGD oxygen–glucose–deprivation, NC negative control, COX5A cytochrome c oxidase subunit 5a over-expression, tunel terminal deoxynucleotidyltransferasedUtp nick end labeling. N = 6/group. Data are presented as the mean ± SD. *p < 0.05, **p < 0.001