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. 2020 Apr 30;18:45. doi: 10.1186/s12915-020-00780-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Detection of human pre-MIR941-1 in mouse embryos. AAV1-encoded pre-MIR941-1 (MIR941) was injected into one striatal hemisphere of three male mice. After 8 weeks post-injection, MIR941 was detected in injection and contralateral sites, cerebellum, lymph node and vas deferens/epididymis (V/E). Injected male mice were mated between 6 and 8 weeks following injection with wildtype female mice. Evidence of MIR941 was detected in 9 of the 18 embryos (7.5 d.p.c.) screened. Rabbit β-globin (rBG) fragment was only found in injection sites and one contralateral site. Positive control (HEK293), negative control (no template control). * Samples that were positive on the gel and were supported by melt-curve analysis (Additional file 5: Supplementary Information)