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. 2020 Apr 29;21:327. doi: 10.1186/s12864-020-6751-5

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Enrichment analysis of CG-type differentially methylated genes. (a) Counts of DMGs enriched for the top 20 muscle development-related Gene Ontology (GO) terms. The abscissa represents the number of DMGs, and the ordinate shows the GO pathway terms. (b) The scatterplot of 21 muscle development-related Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The ordinate represents the enriched pathways, and the abscissa represents the Rich factor of the corresponding pathways; the size of the spots represents the number of genes related to DMRs enriched in each pathway, while the color of the spot represents the corrected P-value for each pathway. The Rich factors indicate the ratio of the number of DMGs mapped to a certain pathway to the total number of genes mapped to this pathway. Greater Rich factor means greater enrichment. DMRs: differentially methylated regions; DMGs: differentially methylated genes