Table 3.
DMGs most likely involved in muscle development
| RNA-seq data | WGBS-seq data | ||||||
|---|---|---|---|---|---|---|---|
| Gene name | FPKM of Fetus | FPKM of Adult | log2FC | MethChr | MethDiff (FetusV Adult) | P-value | Annotation |
| ADIPOQ | 2.7 ± 0.70 | 59.02 ± 8.37 | 5.07 | 1 (198577572–198,577,648) | 0.355 | 1.95E-13 | Distal Intergenic |
| CCNA2 | 3.96 ± 1.32 | 0.22 ± 0.04 | −3.53 | 6 (3651607–3,651,817) | 0.494 | 8.16E-19 | Intron |
| ITGA1 | 6.3 ± 2.32 | 0.22 ± 0.06 | −4.20 | 16 (26099670–26,099,819) | −0.374 | 1.02E-08 | Intron |
| MYOG | 118.2 ± 11.46 | 8.76 ± 1.99 | −3.15 | 12 (196054–196,192) | −0.409 | 2.76E-07 | Exon |
| 12 (220130–220,377) | −0.314 | 4.32E-09 | Distal Intergenic | ||||
| 12 (229114–229,232) | 0.54 | 7.28E-07 | Distal Intergenic | ||||
| MAPT | 1.08 ± 0.27 | 6.49 ± 1.04 | 3.23 | 11 (45304861–45,304,888) | −0.418 | 6.01E-08 | Distal Intergenic |
| 11 (45312449–45,312,737) | −0.308 | 1.53E-10 | Promoter (2-3 kb) | ||||
| 11 (45313729–45,313,893) | −0.34 | 4.93E-09 | Promoter (1-2 kb) | ||||
| 11 (45317381–45,317,584) | 0.399 | 4.47E-20 | Intron | ||||
| 11 (45327134–45,327,228) | −0.519 | 6.13E-12 | Intron | ||||
| 11 (45328297–45,328,427) | −0.372 | 1.50E-07 | Intron | ||||
| 11 (45345547–45,345,760) | −0.368 | 9.78E-08 | Intron | ||||
| 11 (45360455–45,360,557) | 0.371 | 2.30E-07 | Intron | ||||
| 11 (45379302–45,379,326) | −0.374 | 1.46E-08 | Intron | ||||
| 11 (45380382–45,380,415) | −0.413 | 8.46E-09 | Intron | ||||
| 11 (45390429–45,390,641) | 0.368 | 4.67E-06 | Intron | ||||
| 11 (45398919–45,399,057) | 0.371 | 2.28E-08 | Intron | ||||
| 11 (45434897–45,434,935) | 0.522 | 4.15E-08 | Distal Intergenic | ||||
| DIAPH1 | 1.79 ± 0.12 | 9.73 ± 1.47 | 3.08 | 5 (50071804–50,071,997) | −0.382 | 2.45E-16 | Intron |
| 5 (50074050–50,074,580) | − 0.343 | 3.12E-15 | Intron | ||||
| 5 (50078005–50,078,016) | −0.515 | 9.21E-17 | Intron | ||||
| 5 (50093277–50,093,488) | −0.51 | 4.68E-11 | Promoter (1-2 kb) | ||||
| NR4A1 | 1.9 ± 0.64 | 46.14 ± 5.86 | 5.20 | 3 (134110748–134,110,763) | −0.462 | 4.49E-10 | Distal Intergenic |
| 3 (134112701–134,112,875) | −0.4 | 1.53E-08 | Intron | ||||
| 3 (134118207–134,118,238) | −0.474 | 3.23E-06 | Promoter (1-2 kb) | ||||
| DLK1 | 123.79 ± 16.79 | 1.59 ± 0.18 | −5.62 | 18 (64227388–64,227,489) | 0.315 | 4.53E-06 | Distal Intergenic |
| 18 (64229987–64,230,060) | 0.566 | 1.12E-11 | Distal Intergenic | ||||
| 18 (64285447–64,285,772) | 0.315 | 2.15E-09 | Distal Intergenic | ||||
| 18 (64297875–64,297,887) | 0.509 | 2.27E-07 | Distal Intergenic | ||||
| 18 (64322164–64,322,397) | 0.303 | 7.14E-08 | Distal Intergenic | ||||
| 18 (64325751–64,325,850) | 0.31 | 2.10E-05 | Promoter (2-3 kb) | ||||
| 18 (64332000–64,332,064) | 0.361 | 5.28E-05 | Exon | ||||
| 18 (64374254–64,374,306) | 0.372 | 2.43E-05 | Distal Intergenic | ||||
| 18 (64374640–64,374,824) | 0.567 | 2.60E-33 | Distal Intergenic | ||||
| 18 (64379476–64,379,559) | 0.418 | 1.43E-05 | Distal Intergenic | ||||
| COL1A2 | 1509.82 ± 168.72 | 166.04 ± 40.84 | −2.53 | 4 (11479735–11,479,933) | 0.316 | 1.92E-05 | Distal Intergenic |
| 4 (11513253–11,513,266) | −0.37 | 2.60E-06 | Distal Intergenic | ||||
| 4 (11551771–11,551,783) | 0.433 | 2.40E-08 | Distal Intergenic | ||||
| 4 (11553777–11,553,809) | 0.334 | 7.76E-06 | Distal Intergenic | ||||
| 4 (11712184–11,712,329) | 0.309 | 5.19E-12 | Distal Intergenic | ||||
Note: chr: chromosome. DMR: different methylated regions. Meth diff: the difference in methylation levels between Fetus and Adult; a positive number means the methylation levels of this region in the Adult group are higher than those in the Fetus group, and a negative number means that the methylation levels of this region in the Adult group are lower than those in the Fetus group