Table 2.

Molecular targets of (p)ppGpp that have been investigated in Mycobacterium tuberculosis (Mtb).

Molecular targets	Cellular process	Effects in Mtb	References
RNAP	Transcription	Inhibited at high [(p)ppGpp] in vitro	China et al. (2012), Tare, China and Nagaraja (2012) and Tare, Mallick and Nagaraja (2013)
GMK, Guanlyate Kinase	Purine metabolism	Insensitive to (p)ppGpp	Liu et al. (2015)
PPX1 and PPX2, Polyphosphatases	Polyphosphate metabolism	Inhibited by (p)ppGpp in vitro	Choi et al. (2012) and Chuang et al. (2015)