Table 3.

Regulated genes related to Hippo signalling pathway emodin injected group compared to control group.

Gene symbol		Full name	Fold change	Description
Up-regulated genes	Tead4	TEA Domain Transcription Factor 4	4.047	Transcription factor which plays a key role in the Hippo signalling pathway
	Tead1	TEA Domain Transcription Factor 1	1.677	Paralog of TEAD 4
	Stk3	Serine/Threonine Kinase 3	1.509	Repress proliferation of mature hepatocytes
	Mob1b	MOB Kinase Activator 1B	1.356	Binding with LATS1 and phosphorylates and inactivates YAP1
	Lats1	Large Tumour Suppressor Kinase 1	1.151	Inhibiting translocation into the nucleus of YAP1 by phosphorylation
Down-regulated genes	Amotl1	Angiomotin Like 1	0.790	Encoding peripheral membrane protein that is a component of tight junctions
	Limd1	LIM Domains Containing 1	0.761	Involved in several cellular processes such as repression of gene transcription, cell differentiation and proliferation
	Wtip	WT1 Interacting Protein	0.760	Involved transcription corepressor activity
	Fat4	FAT Atypical Cadherin 4	0.340	Plays a role in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation
	Ajuba	Ajuba LIM Protein	0.287	Negatively regulates the Hippo signalling pathway and antagonises phosphorylation of YAP1