Table 1.
Oral pharmacokinetic parameters of TaxolTM (commercial formulation), PTX-loaded CS-SA micelles, PTX-loaded LC-SA/CS-SA micelles plus LC, and PTX-loaded LC-SA/CS-SA micelles in rats.
Parameters | Taxol™ | PTX-loaded CS-SA | PTX-loaded LC-SA/ CS-SA + LC | PTX-loaded LC-SA/ CS-SA |
---|---|---|---|---|
AUC(0–t) (mg/L·h) | 28.98 | 24.43 | 28.24 | 48.05 |
t1/2z | 83.83 | 44.85 | 30.78 | 9.40 |
Tmax (h) | 0.5 | 2 | 2 | 2 |
Cmax (mg/L) | 2.22 | 2.01 | 1.94 | 4.51 |
CLz/F (L/h/kg) | 0.19 | 0.39 | 0.44 | 0.53 |
Vz/F (L/kg) | 23.36 | 25.09 | 19.53 | 7.17 |
Relative bioavailability (%) | – | 84.30 | 97.45 | 165.80 |