Table 2.
Baseline participant characteristics by quartiles of the summary secretion score
| Characteristics | All Participants | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 |
|---|---|---|---|---|---|
| eGFRCRIC, ml/min per 1.73 m2 | 45±17 | 32±11 | 40±13 | 48±13 | 60±16 |
| Age, yr | 58±11 | 59±11 | 58±11 | 58±11 | 56±10 |
| Female | 1531 (45) | 449 (53) | 427 (50) | 344 (40) | 305 (36) |
| Black | 1410 (41) | 406 (48) | 359 (42) | 322 (38) | 317 (37) |
| Hispanic | 405 (12) | 141 (17) | 112 (13) | 90 (11) | 62 (7) |
| BMI, kg/m2 | 32±8 | 31±8 | 32±8 | 32±7 | 33±8 |
| Education categories | |||||
| Less than high school | 678 (20) | 250 (29) | 191 (22) | 143 (17) | 94 (11) |
| High school graduate | 647 (19) | 186 (22) | 168 (20) | 151 (18) | 142 (17) |
| Some college | 983 (29) | 246 (29) | 238 (28) | 255 (30) | 244 (29) |
| College graduate or higher | 1097 (32) | 169 (20) | 255 (30) | 303 (36) | 370 (44) |
| Current smoker | 435 (13) | 132 (16) | 106 (12) | 99 (12) | 97 (11) |
| History of diabetes | 1637 (48) | 412 (48) | 434 (51) | 421 (49) | 367 (43) |
| History of cardiovascular disease | 1142 (33) | 351 (41) | 302 (35) | 284 (33) | 200 (24) |
| History of peripheral vascular disease | 232 (7) | 87 (10) | 60 (7) | 43 (5) | 42 (5) |
| Systolic BP, mm Hg | 128±22 | 133±25 | 128±22 | 126±20 | 124±19 |
| Laboratory measurementsa | |||||
| Serum albumin, g/dl | 3.9±0.5 | 3.9±0.5 | 3.9±0.5 | 4.0±0.5 | 4.0±0.4 |
| 24-h urine albumin, g/24 h | 0.7+1.7 | 0.8±1.6 | 0.8±1.9 | 0.7±1.6 | 0.5±1.5 |
| Phosphate, mg/dl | 3.7±0.7 | 4.0±0.7 | 3.8±0.6 | 3.6±0.6 | 3.5±0.5 |
| HDL, mg/dl | 48±16 | 47±16 | 48±15 | 47±15 | 48±15 |
| Total bicarbonate, mEq/L | 24.4±3.2 | 23.4±3.4 | 24.3±3.2 | 24.7±3.0 | 25.3±3.0 |
| Hemoglobin, g/dL | 12.6±1.8 | 12.0±1.7 | 12.4±1.6 | 12.8±1.8 | 13.2±1.7 |
| Medications | |||||
| Insulin | 824 (24) | 211 (25) | 233 (28) | 214 (25) | 166 (20) |
| Statin | 1872 (55) | 455 (54) | 483 (57) | 489 (58) | 439 (52) |
| ACEi/ARB | 2323 (68) | 526 (62) | 624 (73) | 624 (73) | 544 (64) |
| Loop diuretic | 1276 (38) | 437 (52) | 363 (43) | 270 (32) | 204 (24) |
| Thiazide diuretic | 966 (28) | 184 (22) | 255 (30) | 281 (33) | 244 (29) |
For continuous variables, mean±SD; for categoric variables, N (%); unless otherwise specified. eGFRCRIC, glomerular filtration rate estimated based on serum creatinine and cystatin C concentrations, age, sex, and Black race using an equation that was developed in a subcohort of 1433 CRIC participants who underwent 125-Iothalamate GFR clearance studies; ACEi, angiotensin-converting enzyme inhibitors; ARB, angiotensin receptor blockers.
a
Conversion factors for units: albumin in g/dl to g/L, ×10; phosphate in mg/dl to mmol/L, ×0.3229; HDL in mg/dl to mmol/L, ×0.02586; bicarbonate in mEq/L to mmol/L, ×1; hemoglobin in g/dl to g/L, ×10.