Table 3.
In-Hospital Mortality by Urine Diagnostic Result and Meningitis Aetiology by Univariate Logistic Regressiona
| Alere TB-LAM | Xpert MTB/RIF Ultra | Either TB Assay Positiveb | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Study Population | Positive | Negative | Odds Ratio (95% CI) | P Value | Positive | Negative | Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value |
| Overall | 32% (22 of 68) | 26% (60 of 229) | 1.35 (0.75–2.42) | .32 | 36% (10 of 28) | 24% (51 of 214) | 1.78 (0.77–4.09) | .18 | 1.44 (0.83–2.49) | .19 |
| Cryptococcal | 32% (12 of 38) | 27% (36 of 133) | 1.24 (0.57–2.72) | .59 | 50% (3 of 6) | 23% (28 of 121) | 3.32 (0.63–17.4) | .16 | 1.41 (0.67–2.96) | .37 |
| TBM, definite | 38% (5 of 13) | 32% (7 of 22) | 1.34 (0.32–5.61) | .69 | 50% (7 of 14) | 15% (3 of 20) | 5.67 (1.13–28.5) | .04 | 3.00 (0.71–12.7) | .14 |
| TBM, probable | 50% (4 of 8) | 38% (5 of 13) | 1.60 (0.27–9.49) | .60 | 0% (0 of 4) | 50.0% (7 of 14) | ||||
| Other/unknown | 11.1% (1 of 9) | 19.7% (12 of 61) | 0.51 (0.06–4.48) | .54 | 0% (0/4) | 22% (13/59) | 0.34 (0.04–2.84) | .32 | ||
Abbreviations: CI, confidence interval; TB, tuberculosis; TB-LAM, TB-lipoarabinomannan; TBM, tuberculous meningitis.
aData represent mortality by TB test status. Hospital outcome was unknown for 34 participants (7.5% of cryptococcal, 7.5% TBM definite, 5% TBM probable, 17% unknown/other meningitis). Among those who are known to have died in hospital, the median time to death was 7 days (interquartile range, 3–12 days).
bEither TB assay positive is any positive urine diagnostic (TB-LAM or Ultra or both) versus both assays being negative.