Table 1.
Analysis of the number of ssRNA fragments from the coronavirus whole genome recognized by TLR7/8.
| Genome | SARS-CoV | MERS-CoV | SARS-CoV-2/Wuhan | SARS-CoV-2/Germany |
|---|---|---|---|---|
| Reference Sequence: | NC_004718.3 | NC_019843.3 | EPI_ISL_402123 | EPI_ISL_406862 |
| U % (bp) | 30.73 (9143) | 32.94 (9799) | 32.24 (9593) | 32.16 (9567) |
| A % (bp) | 28.51 (8481) | 26.55 (7900) | 30.08% (8949) | 29.89 (8893) |
| C% (bp) | 19.97 (5940) | 20.56 (6116) | 18.46 (5492) | 18.39 (5471) |
| G % (bp) | 20.80 (6187) | 21.19 (6304) | 19.71 (5865) | 19.67 (5851) |
| Total nucleotides (bp) | 29,751 | 30,119 | 29,899 | 29,782 |
| The number of oligonucleotide fragments recognized by TLR7 | ||||
| Motif fully bound | ||||
| UUU | 603 | 655 | 708 | 706 |
| (UUU)2 | 2 | 4 | 4 | 4 |
| UUC | 563 | 581 | 518 | 513 |
| (UUC)2 | 13 | 14 | 15 | 15 |
| (UUC)3 | 1 | 0 | 3 | 3 |
| Motif moderately bound | ||||
| UUA | 689 | 791 | 876 | 873 |
| (UUA)2 | 22 | 30 | 25 | 25 |
| (UUA)3 | 3 | 1 | 0 | 0 |
| aUUG | 776 | 846 | 817 | 817 |
| (UUG)2 | 24 | 31 | 22 | 22 |
| (UUG)3 | 0 | 1 | 0 | 0 |
| The number of oligonucleotide fragments recognized by TLR8∗ | ||||
| UG | 2664 | 2704 | 2589 | 2586 |
| (UG)2 | 199 | 191 | 175 | 174 |
| (UG)3 | 16 | 16 | 12 | 12 |
| (UG)4 | 3 | 1 | 1 | 1 |
| (UG)5 | 1 | 0 | 0 | 0 |
a
UUG motifs are also recognized by TLR8.