Table 4.
Results of Changes in Bone Mass and Bone Resorption/Formation Markers During Testosterone Replacement Treatment
| Treatment duration, mo | ||||||
|---|---|---|---|---|---|---|
| 0 | 2 | 11 | 33 | Reference | ||
| Femur | BMD, g/cm2 | 0.435 | 0.483 | 0.505 | 0.473 | |
| T score | –3.4 | –3 | –2.8 | –3.1 | ||
| Z score | –3.3 | –2.9 | –2.8 | –3 | ||
| BMC, g | 2.55 | 2.43 | 2.98 | 2.56 | ||
| Lumbar | BMD, g/cm2 | 0.47 | 0.517 | 0.54 | 0.657 | |
| T score | –4.9 | –4.5 | –4.3 | –3.3 | ||
| Z score | –4 | –3.7 | –3.5 | –2.7 | ||
| BMC, g | `19.61 | 21.98 | 23.27 | 27.1 | ||
| Bone Resorption/ Formation Markers | BAP, U/L | 41.3 | 28.5 | – | 12.5 | 3.7-20.9 |
| sNTx, nmolBCE/L | 48.2 | 34.2 | – | – | 9.5-17.7 | |
| TRACP-5b, mU/dL | 489 | 357 | – | 133 | 170-590 |
–, not measured.
Abbreviations: BAP, bone-specific alkaline phosphatase; BMC, bone mineral content; BMD, bone mineral density; sNTx, serum N-telopeptide; TRACP-5b, tartrate-resistant acid phosphatase 5b.