Table 2.—

Hazard Ratios (95% CI) of Dementia in Relation to Baseline Headache Status, ARIC 1993–2017

	No Headache	Severe Non-Migraine Headache		Migraine
	n Total = 9855	n Total = 1243		n Total = 1397
	n Events = 1821	n Events = 196		n Events = 233
Model 1 HR	1 (Ref)	1.00 (0.86, 1.16)		1.02 (0.89, 1.17)
Model 2 HR	1 (Ref)	1.00 (0.87, 1.17)		1.04 (0.91, 1.20)
	No Headache	Severe Non-Migraine Headache	Migraine Without Aura	Migraine With Aura
	n Total = 9855	n Total = 1243	n Total = 992	n Total = 405
	n Events = 1821	n Events = 196	n Events = 165	n Events = 68
Model 1 HR	1 (Ref)	1.00 (0.86, 1.16)	0.99 (0.84, 1.16)	1.11 (0.87, 1.42)
Model 2 HR	1 (Ref)	1.00 (0.87, 1.17)	1.01 (0.86, 1.19)	1.12 (0.88, 1.43)

Model 1: age, sex, race-center, APOE ε4, income, and education.

Model 2: Model 1 + BMI, smoking status, hypertension, diabetes, prevalent CHD, drinking status, HDL cholesterol, and total cholesterol.

CI = confidence interval; HR = hazard ratio.